Authors: S. Sivalakshmi, Maruti Rao
Abstract: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine diseases affecting women of reproductive age, with a worldwide incidence of 5-10%. PCOS is distinguished by hyperandrogenism, irregular menstrual periods, polycystic ovaries, insulin resistance, and obesity, particularly of the abdominal kind. PCOS is a multigenic complicated condition that causes metabolic and gynaecologic dysfunctions in women of reproductive age. The family clustering of PCOS women shows that genetics is involved in the development of this condition. PCOS is currently thought to be a polygenic characteristic caused by the combination of numerous vulnerable and protective genetic variations, as well as the effect of environmental variables. The paraoxonase 1 (PONI) gene encodes an antioxidant enzyme that inhibits LDL oxidation and hence atherosclerosis. In our PCOS patients, serum paraoxonase levels were considerably lower.
Keywords: Herbal treatment, Pathophisiology, Polycystic ovarian syndrome (PCOS), Hyperandrogenism, Ovulatory dysfunction
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