Advanced Drug Delivery Systems (DDS): Innovations and Therapeutic Prospects

Abstract

The field of drug delivery has witnessed remarkable progress in recent decades, transitioning from conventional dosage forms to sophisticated systems capable of targeted, controlled, and stimuli-responsive drug release. Advanced drug delivery systems (DDS) aim to optimize therapeutic efficacy while minimizing side effects, improving patient compliance, and addressing challenges such as poor solubility, rapid clearance, and multidrug resistance. This review highlights the current landscape of advanced DDS, focusing on nanocarriers, polymeric systems, liposomes, micelles, dendrimers, hydrogels, and emerging technologies such as stimuli-responsive and biologically inspired delivery systems. Additionally, we discuss the clinical applications, challenges, and future directions of DDS, emphasizing the role of personalized medicine in shaping next-generation therapies.

KEYWORDS: Drug delivery systems, nanocarriers, liposomes, stimuliresponsive delivery, polymeric nanoparticles, targeted therapy.