Role of Polymers in Controlled Drug Release Formulations: A Pharmaceutical Perspective

Abstract

Controlled drug delivery systems have revolutionized the pharmaceutical industry by offering consistent therapeutic levels, reduced dosing frequency, and improved patient compliance. This paper examines the use of synthetic and natural polymers in the design of controlled release formulations. Through experimental formulation and analysis, the study explores hydrophilic and hydrophobic polymers like HPMC, ethyl cellulose, and chitosan in tablet matrices. Various release kinetics models were applied to evaluate drug release profiles. The findings indicate that polymer type and concentration significantly influence the release rate and mechanism. The optimization using response surface methodology (RSM) revealed the ideal formulation variables for sustained delivery of a model drug (metformin). The study emphasizes the critical role of polymer chemistry in the development of advanced pharmaceutical formulations.

Keywords: Controlled Release, Pharmaceutical Polymers, Drug Delivery, Release Kinetics, Formulation Optimization