Green Chemistry in Pharmaceutical Formulations: Sustainable Synthesis of API’s

Abstract

The environmental footprint of pharmaceutical manufacturing has prompted the adoption of green chemistry principles in drug synthesis and formulation. This paper explores eco-friendly methodologies in pharmaceutical chemistry that reduce waste, energy consumption, and hazardous reagent use. A case study on the green synthesis of paracetamol using biocatalysts and solvent-free conditions is presented. The study also evaluates the environmental impact using E-factor and atom economy metrics. The final formulation was assessed for quality attributes and bioequivalence with conventionally synthesized counterparts. Results confirm that green chemistry does not compromise efficacy and presents a viable alternative to traditional synthetic routes. This research advocates for a shift towards sustainability in drug development practices.

 Keywords: Green Chemistry, Sustainable Formulation, Biocatalysis, Atom Economy, Environmental Metrics