Advanced Drug Delivery Systems: Nanoparticulate Formulations for Targeted Cancer Therapy

Abstract

Conventional chemotherapy suffers from lack of specificity, leading to systemic toxicity and reduced efficacy. This paper explores the advancements in drug delivery using nanoparticulate systems to enhance targeted therapy for cancer. Through pharmaceutical chemistry, various nano-formulations such as liposomes, dendrimers, and polymeric nanoparticles are engineered to improve drug solubility, stability, and bioavailability. The study provides an in depth analysis of the synthesis of doxorubicin-loaded PLGA nanoparticles and evaluates their targeting efficiency through ligand modification. Characterization techniques included DLS, SEM, and FTIR. The in-vitro cytotoxicity studies revealed increased selectivity towards cancerous cells, with minimal impact on normal tissues. The findings reaffirm the importance of nanotechnology in overcoming the limitations of traditional drug delivery methods and enhancing therapeutic outcomes.

Keywords: Nanoparticles, Targeted Drug Delivery, Cancer Therapy, Doxorubicin, Ligand Conjugation