Green Analytical Chemistry In Pharmaceutical Research: A Sustainable Approach

Abstract

The pharmaceutical industry is increasingly adopting green analytical chemistry (GAC) principles to minimize environmental impact and enhance sustainability. This paper reviews eco-friendly analytical practices such as solvent-free extraction, miniaturized chromatography, and the use of biodegradable reagents. The implementation of microwave-assisted extraction, supercritical fluid chromatography, and deep eutectic solvents has significantly reduced waste generation and energy consumption. The study also outlines regulatory guidelines promoting sustainable analytical approaches under the concept of Green Analytical Procedure Index (GAPI) and Analytical Eco-Scale. The integration of automation and microfluidic technologies further supports energy-efficient and cost-effective analysis. Overall, the paper underscores the necessity of embedding sustainability into every stage of pharmaceutical drug analysis and development.

Keywords: Green Chemistry, Sustainable Analysis, GAPI, Microfluidics, Eco Scale