Molecular Correlates of Twak Vikriti (Skin Disorders): Transcriptome and Proteome Profiling Insights into Vicharchika (Eczema) And Shwitra (Vitiligo) With Emphasis on Traditional Ayurvedic Perspectives and Modern Systems Biology

Abstract

Authors: Dr. Ananya Srivastava, Dr. Rohan Kulkarni

ABSTRACT: Skin, as the most visible and dynamic organ of the human body, plays a pivotal role in both physiological and psychosocial health. In Ayurveda, skin disorders are classified under Twak Vikriti, with conditions such as Vicharchika (akin to eczema/dermatitis) and Shwitra (comparable to vitiligo) being emphasized due to their chronicity and impact on quality of life. Modern omics technologies, particularly transcriptome and proteome profiling, have enabled unprecedented insights into the molecular underpinnings of such diseases. This paper attempts to bridge the Ayurvedic conceptual framework of dosha imbalance with current findings from systems biology, outlining how immune dysregulation, oxidative stress, altered cytokine networks, and melanocyte dysfunction correspond to the classical descriptions of Twak Vikriti. Furthermore, the challenges, opportunities, and future directions for integrative research are presented, highlighting the potential for developing novel therapeutics and diagnostic strategies by combining traditional knowledge with molecular sciences.

KEYWORDS: Twak Vikriti, Vicharchika, Shwitra, Transcriptomics, Proteomics, Ayurveda, Skin Disorders, Systems Biology, Molecular Correlates, Dosha Imbalance